10 Of the Best Natural Nootropic Supplements

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Natural Nootropic Supplements That are Safe and Effective

Do one search online or look around in your local health food store and you can find a lot of natural supplements that are actually nootropic in nature. There are a good number that have the same qualities as others so it is important to realize that not everything works for everyone. You may have to try a few before you find what works for you. My list below consists of 10 effective natural nootropics that may work for you.


Huperzine A

Huperzine A has the ability to protect our brains from oxidative damage which is very often associated with getting older. This oxidative damage is at the core of Alzheimer’s disease and other degenerative disorders. 1

Studies are finding that Huperzine A may improve cognitive function of those suffering a brain injury and significantly improving the cognitive function and overall symptoms in Alzheimer’s patients.Natural nootropic supplements

Cognitive Abilities

Huperzine A has the ability to improve our memory by elevating the levels of Acetylcholine in our brains. Acetylcholine is a neurotransmitter very important to every aspect of cognition. [4]

This is of great importance to Alzheimer’s sufferers, but it also has the benefit of improving memory and learning in those who are generally healthy.


Anxiety and Depression

Anxiety and depression are very much neurological issues and Huperzine A has shown promise in these areas.

One study on huperzine A showed that it had specific biochemical interactions for anxiety. It blocks receptors that increase anxiety and alter neurotransmitters that cause anxiety. [5]

As for depression, a 2017 study revealed that the plant chemical could behave very much like a natural anti-depressant, though how effective it is compared to pharmaceutical anti-depressants is still uncertain.[6]

To read more about or to buy Huperzine A, read my Huperzine A review here.


When you think of Creatine you almost always think of muscle building because it works very well at building muscle. However, its health benefits don’t end there, It’s a very good nootropic that has significantly increased your mental performance such as memory, the speed of brain performance and your intelligence.

Creatine is found in all red meats and you can easily buy it in large quantities of powder at health food and bodybuildingNatural nootropic supplements


Creatine is found mostly in red meats as well so it is easy to include this in your daily routine to build both muscle and your brain processing.

Improves brain energy levels

Creatine is a molecule that allows cells to store energy in our brains for another time. The stored energy then gets used when you want to be more productive or study better etc.

The work Caffeine sometimes comes up in discussions about Creatine, but let me assure you, Creatine does not feel like Caffeine use.

Improves reasoning skills

Many nootropics improve memory or focus and attention, but creatine is one of the few that enhances reasoning as well. Memorizing information is useful, but reasoning logically through a difficult professional or educational problem is even more profound.


Rhodiola Rosea

Many studies have proven that Rhodiola is a stress reducer, helps rid you of brain fog, and helps prevent fatigue.

Another name you may be familiar with that Rhodiola Rosea goes by is Arctic Root. Arctic Root has been proven in many studies to be a stress reducer, to help get rid of brain fog, and to prevent fatigue.

Rhodiola helps our bodies adapt to stress by modulating our stress hormones [7]. When we get stressed our stressNatural nootropic supplements

hormone levels increase and we feel nervous, anxious, and edgy. This will over time lead to fatigue. What Rhodiola does is to prevent these stress hormones from increasing too much.

Balances our Mood

Studies show that Rhodiola enhances Seratonin, Dopamine and endorphin levels in our brains. [8]. Keeping these levels normal is needed to keep our mood balanced so we can keep calm and remain positive. Dopamine keeps us moving towards completing our goals and keeps our self-esteem high and our confidence high. Endorphins help our mood and keep us feeling good.

To read more about or to buy Rhodiola Rosea, read my Benefits of Rhodiola Rosea article here.

Bacopa Monnieri

Bacoba Monnieri is another natural supplement used for many thousands of years. Traditionally it is used in Ayurvedic medicine which is one of the world’s oldest holistic (“whole-body”) healing systems. It was developed more than 3,000 years ago in India and is used in brain function. A study found that Bacopa Monnieri improves cognitive function and also decreased anxiety and depression in the elderly who did not have Alzheimer’s disease.Natural nootropic supplements

Memory and Brain Function

Many studies have shown that Bacopa Monierri can help us keep our memories better and enhance our cognitive function.

A report completed in 2014 that analyzed nine studies done on the effect of Bacopa Monnieri on cognitive function showed that indeed the research was correct. Bacopa has the potential to improve cognition, but larger studies are still needed.[9]

Another review was done on previous studies for cognitive performance and did conclude that Bacopa may improve memory.[10]

In a 2016 study of 60 college students given 300mg/day of Bacopa for six weeks led to improvements in cognitive functions tests.[11]

If you would like more information on Bacopa Monierri or to buy, check out my Bacopa Monnieri Supplement article

Lion’s Mane

Lion’s Mane (Hericium erinaceus) is white, globe-shaped fungi that have long, shaggy spines. People can eat them or take them in the form of supplements. It contains compounds called hericenones and erinacines that may have neuroprotective and cognitive-enhancing effects.

Enhanced Memory and Brain Function

In a 2009 Japanese clinical trial lasting 16 weeks, healthy adult participants with mild cognitive impairment were given 3 grams of the extract. Testing was done throughout the study and right to the end cognitive function scores continually increased but went back to normal when they stopped taking the Lion’s Mane. [12][](https://www.ncbi.nlm.nih.gov/pubmed/18844328)

What has been concluded is that Lion’s Mane has the potential to enhance our cognitive function not only in healthy Natural nootropic supplements

people but in Alzheimer’s sufferers as well.

Depression and Anxiety

Lion’s Mane may help improve symptoms of anxiety and depression.

In 2010 a study was done to test this. It included 30 women where over four weeks 15 were given Lion’s Mane and the other 15 a placebo. When the study ended, results showed the women who had taken the Lion’s Mane had less anxiety and better sleep quality than those who took the placebo.[13]

It may be that lion’s Mane could boost cognitive function, but the only research to date is on animals. There are positive results however and research is ongoing.

If you are looking to get yourself some Lion’s Mane you can get it right here at Amazon

For my complete review of Lion’s Mane and to Get some follow this link.


Citicoline is a chemical that occurs naturally in the brain. It is currently used to help treat Alzheimer’s and other forms of age-related dementia. It is also used in head injury and age-related memory loss. It also has a positive effect on attention deficit hyperactivity disorder (ADHD). Studies show that it can significantly improve cognitive impairments, especially those caused by vascular diseases (such as multiple small strokes and arteriosclerosis), and can improve Natural nootropic supplements

memory and recall in elderly patients without dementia.

Citicoline works by helping to enhance circulation to the brain by improving neuroplasticity or our brain’s ability to recover and rebuild.

Although used with the elderly, Citicoline isn’t reserved for the elderly. Studies show we can all benefit from it with improved motor speed. It obviously will help in adolescents ability to pay attention longer.

Those who take citicoline regularly have been shown to show improved attention and as a result make fewer mistakes whee attention is needed.

For my complete review of Lion’s Mane and to Get some follow this link.


This little gem is known to help with concentration, attention, and alertness resulting in producing a calm state with those who take it. L-theanine is found in black, green and white tea

What it does is increases serotonin, dopamine, and GABA which improve our mood, ability to learn, and of course our memory. I don’t like to talk about caffeine too much even though it is a natural nootropic, but if you combine L-theanine and caffeine it has been shown people have improved their accuracy and speed on some cognitively difficultNatural nootropic supplements

and demanding jobs.

Reduces Anxiety

L-theanine can reduce the symptoms of anxiety because it closely resembles the neurotransmitter glutamate. Glutamate is considered the brain’s most important excitatory neurotransmitter, while L-theanine is inhibitory. These two closely resemble each other so L-theanine can provide a calming effect that relieves anxiety[14].

L-Theanine and Stroke Reduction

L-theanine has properties that can help prevent strokes and lessen the damage caused by a stroke.

L-theanine increases nitric oxide production in cells. Nitric oxide is absolutely essential for relaxing your arteries so blood can flow freely, reducing the chance of having a stroke.[15]

Find out a lot more about L-theanine from my comprehensive look at the benefits of l-theanine.

American Ginseng (Panax Quinquefolius)

American ginseng (Panax quinquefolis) is a herb that grows mainly in North America and is in such high demand that it is actually been deemed an endangered species in a few American States. It’s no wonder with all it can do for us.

Benefits Brain Function

Ginseng could help improve brain functions like memory, behaviour and mood.Natural nootropic supplements

One study on brain function benefits was conducted with 30 healthy participants. They were given 200mg/day of Ginseng for four weeks. The study resulted in the participants having improved mental health, social function, and mood.

The problem was that extending the use of Panax Ginseng, the benefits began to subside. This suggests that long term use of the supplement may not be beneficiary without cycling. [16]


Taurine is widely used to improve physical importance and you often find it as an ingredient in energy drinks.

In human studies, athletes who consumed taurine did improve their performance. Runners and cyclists found less fatigue over longer distances.

Taurine also has a role in reducing muscle damage as found in those who weight lift. Those taking taurine were found to have fewer markers of damage and muscle soreness.


Ginkgo Biloba

Ginkgo is known for its very high level of antioxidants like flavonoids and terpenoids and this is considered to be behind the many health benefit claims it has. High levels of flavonoids and terpenoids

Antioxidants fight to neutralize free radical damage. Free radicals are reactive particles our body produces during our Natural nootropic supplements

normal metabolism for example digestion where food is converted to energy.

Antioxidants combat or neutralize the damaging effects of free radicals.

Ginkgo is used for poor concentration, memory loss, fatigue, mental confusion, depression, or anxiety.

To read more about or to buy Ginkgo Biloba you can find my benefits of ginkgo biloba supplements article here

If you are looking for a very effective all natural nootropic stack that benefits your attention, memory, focus, ability to learn new things, and your concentration, look no further than Performance Lab Mind.

You can read about Performance Lab Mind in my Performance Lab Mind Review here


12 thoughts on “10 Of the Best Natural Nootropic Supplements”

  1. Thank you for this great post on the best natural nootropic supplements. I was interested to read that you recommend taurine, I had not realised that this was natural as you often hear bad things about taurine and thatyou should limit your intake. Do you think it is important to limit your intake?

    • lChris,

      There are no documented issues with taking taurine at all.  It has gotten a bad rap after some energy drinks Containing taurine and caffeine were banned in Europe after some deaths attributed to the use of the drinks.  The thought is however that the large amount of caffeine was to blame and certainly not the taurine.

      Hope that helps

  2. I found this article to be very helpful for me, I even did not know that some of this supplements are nootropical. I am using creatine powder and it work very well ehwn it comes to building muscle mass. I will start using Huperzine A as I see that it is good for memory and it would be good for school exams.

  3. I must say I hadn’t heard of many of these supplements until now! I love learning about the health benefits of supplements.

    I’m particular interesting in the Rhodiola Rosea for brain fog and fatigue, its a bonus that it increases mental performance and concentration! Do you know if it is safe to take with prescribed medicines or is a case of probably best to consult my doctor?

    • There are no known side effects or interactions with other drugs.  That said I’m not a doctor and will say check with yours just to be on the safe side

  4. Thanks for this great resource on Nootropic Supplements! I think I previously knew Nootropics as being good for cognitive functions, but that was about it as far as my understanding of them went. It’s good to be able to read about them in more depth; you’ve covered a lot of the information that I was missing. I had no idea that Creatine could be used as a Nootropic, that was surprising- I thought it was JUST for bodybuilding. I guess not! Which of these supplements is your personal favorite?

    • my favorite are what I use right now.  Creatine and taurine for my gym routine and ginkgo for cognitive improvements.

      Thanks for taking the time to comment!

  5. Hi, 

    Fascinating article, I have a lot of experience using creatine. As you mention it’s great for helping with muscle mass gains and it also helps increase testosterone production, so it’s one of my favourite supplements. What I didn’t realise is that it can help improve brain processing speeds & intelligence, Taurine is also a supp I’ve previously taken for working out, it looks like I should look at adding it back to my supps drawer. Thanks for sharing this!

    • yes creatine and taurine should be part of your gym regiment daily for best results.  My guess is you already know how to use creatine properly

  6. Thank you for sharing with us this great review about 10 of the best natural Nootropic supplements.Our body needs to be protected and its protection is found in food.Some food can be harmful others are helpful.What is needed is information about what is needed to get well.

    Fortunately this post contains different types of food which can help our body and that is very useful to me.

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