Huperzine A Review – Enhance Your Memory

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Introduction to this Huperzine A Review

This Huperzine A review will show just how important this nootropic is to our brain health.  Huperzine A is a natural plant-based neuroprotector found in may herbs that are known to have enhanced memory and learning properties. It is mostly extracted from the Chinese club moss called Huperzia Serrata. Huperzine A has been used in Chinese herbal medicine for a long time even many centuries.

Huperzine A is very useful because of its ability to inhibit an enzyme in our brains that breaks down an important chemical known as Acetylcholine. Acetylcholine is very important for our memories and our learning ability.

While Huperzine A is closely associated with Alzheimer’s and other forms of dementia as well as depression, Huperzine A can be used by people who are ‘brain healthy’. It is a potent memory enhancement supplement and can help you think more clearly.

Huperzine A is used by University students worldwide as a supplement to boost their cognitive abilities and is one of my choices for best nootropics for focus.  You can also find it as one of my top 10 natural nootropics.


Here’s What Huperzine A Can Do For You

It’s a Memory Enhancer:

Huperzine A increases your levels of acetylcholine, therefore, improving your memory. Studies show that it significantly inhibits acetylcholinesterase production. Acetylcholinesterase is an enzyme which breaks down acetylcholine. By inhibiting this enzyme Huperzine A plays a big part in raising the levels of acetylcholine in our brains and of course, that enhances our cognition and our memory.

Enhance Memory & Learning of Adolescent Students

In a fairly small, double-blind, placebo-controlled study, 34 pairs of middle & junior school aged adolescents who complained about memory were chosen to receive administration of either 100 mcg Huperzine A or placebo daily for a 4-week period. By the end of the study, the researchers found the Huperzine A group scored better on the Memory Quotient tests than the placebo group, leading to the conclusion that this nootropic supplement enhances the memory and learning performance of adolescent students namely on language. [1]


May Help Maintain Healthy Brain Functionhuperzine a review

Huoperzine A also has the benefit of being able to maintain healthy brain function.  A number of animal studies have shown us that it is very good at protecting neurons.[2]

In 2006, an article was written to review studies done on Huperzine A.  What was noted was that stage IV clinical trials were being done on the elderly in China[3] and that they suggest that Huperzine A has the potential to help maintain a healthy brain.

Relieves or Lowers Symptoms of Depression

Huperzine A is used for many purposes, and, among them, it is used as a natural antidepressant. Unlike other antidepressants, Huperzine A does not act directly against depression, but it helps our brain function normal, which is an important aspect of combating depression.

Another review done in 2016 of three clinical trials are telling us Huperzine A may have the benefit of alleviating cognitive impairment symptoms of major depressive disorders. [4].  In these trials, they used 238 participants ranging in age from 16 up to 60.  The trials compared the effectiveness of treating depression with Huperzine A.  The treatment didn’t work for depression, however, it did significantly improve the cognitive functioning and quality of life.

How does Huperzine A work for depression

Depression is caused by a whole host of different external or internal factors. Looking at it from the physiological side, the lack of or insufficient amount of some neurotransmitters in our brains can play a large part in causing depression. Given that, Huperzine A as I mentioned above prevents the breakdown of acetylcholine in our brains effectively preserving brain health.

Huperzine isn’t an antidepressant nor does it act as an antidepressant, but Huperzine A helps alleviate the symptoms of depression by way of it keeping up our brain’s health.

For example, a 2016 review of three clinical trials suggests that Huperzine A may be effective in alleviating the cognitive impairment symptoms of major depressive disorders. A total of 238 people aged 16 to 60 were involved in the trials, which compared the effectiveness of antidepressant treatment to treatment with antidepressant supplemented with huperzine A. While the addition of huperzine A did not appear to treat the depressive disorders, the group who took both antidepressants and huperzine A showed significantly greater improvement in both cognitive functioning and quality of life.

Glutamate Toxicity Protection

What is Glutamine toxicity? First, Glutamate is a powerful neurotransmitter which sends signals between nerve cells. If present in normal levels Glutamine plays a very important role in learning and memory. When levels are too high it may become toxic to our brains and lead to cellular death. Chronic glutamate toxicity caused by oversensitive receptors is associated with neurodegenerative diseases and causes anxiety, restlessness, increased sensitivity to pain, and a diminished ability to focus or concentrate.

Huperzine A has been shown to act as an antagonist to glutamate receptors in the brain, preventing neurons from being over activated by glutamate. This action helps normalize glutamate levels.


Reduces Brain Fog

Studies also show that huperzine A can help with brain fog or mental fatigue.

One study in fact connected the folk herbalism use of clubmoss for chronic fatigue issues to its huperzine A content [5].

What’s more, brain fog isn’t an issue that just happens on its own. It can be a frustrating consequence of other health problems such as autoimmune disorders, digestive dysfunction, certain nervous conditions, or adrenal fatigue.


Huperzine A Could Protect Your Liver

Huperzine A isn’t just a nootropic, it has some other far-reaching benefits up its sleeve.

Many years ago and in the here and now, Huperzine A in Chinese medicine has been used for liver problems.

A study in 2013 showed that its AChE inhibiting benefits apparently reduce inflammation in the liver, thereby enhancing its health and function [6].


 May Help With Addiction

There is one study, although results are very preliminary that shows Hup A may be able to slow or alter the immediate response to addiction, showing promise for the further development and exploration in the alkaloid for addiction treatment and management [7].

It’s untested for now, but huperzine A may provide support for those or trying to quit smoking or drinking, or even heavy drugs however more studies are needed.

Side Effects

Huperzine A is a great nootropic and natural at that, but it does have its own side effects you must be aware of. They include:

  • Rashes and or hives as part of an allergic reaction
  • nausea
  • diarrhea
  • anxiety
  • restlessness
  • hypertension (high blood pressure)

Huperzine-A can be toxic if used in larger than recommended doses. Or if you already have too much acetylcholine(ACh) in your system. Remember, Hup-A boosts levels of ACh.

Symptoms of acute toxicity are similar to those of other cholinergic inhibitors. And can include muscle tremors, drooling, tears, bronchial mucus and incontinence.

Do not use Huperzine-A if you’re dealing with epilepsy. And if you have heart disease, use Hup-a with caution. It can slow the heart rate.

Huperzine A may interact poorly with anticholinergic medications such as Atropine and Scopolamine; it may also interact with antihistamines and antidepressant medications.‍  Those who are taking these medicines or who have heart disease, hypertension, or are taking anticholinergic medications for Alzheimer’s or glaucoma should discuss huperzine A with their doctor before taking it.



As is fairly normal for supplements, there are no medically recognized guidelines for Huperzine A dosage, but from manufacturers guidelines, a dosage of 50–200 mg twice daily for the treatment of Alzheimer’s disease, and 100 mg twice daily to improve memory in adolescents with or without food at any time of day.

Due to its long half-life of over 10 hours, cycling may be useful. A cycle of 2–4 weeks of supplementation followed by a break from supplementation is typical.


My Conclusion

Unfortunately, Huperzine A has been an underdog or underrated nootropic, but shouldn’t be. It has its own powerful benefits to us as a memory enhancer, neuroprotectant, and reliever of symptoms of depression and helps treat neurodegenerative diseases such as Alzheimer’s. This is impressive on its own. Being what it is, it is a great nootropic to combine (stack) with other nootropics. It is safe and well tolerated when taken in moderation.huperzine a review

In fact, Huperzine A often has its effects elevated when used as a stack with other nootropics. If you take it with a choline source, such as Alpha GPC, you can experience a far greater improvement in memory and mental function.

Stacking Huperzine A with a choline source and a racetam, such as piracetam or aniracetam, can provide immense benefits. The added choline, along with Huperzine A’s effects, will combine very well with the racetam and you will probably notice a sense of mental clarity much stronger than that provided by the use of any individual nootropic.


Where to Buy Huperzine A

Huperzine A is a relatively safe nootropic, but a rare one. You may not find huperzine A for sale at your local health food store and it is best to search online for the natural supplement. A good place to start is the NootropicsDepot by clicking here or on the bottle to the right.

12 thoughts on “Huperzine A Review – Enhance Your Memory”

  1. I have a big test coming up for my masters in Audio Engineering, and at the moment I am completely struggling with overload of information…and my studying is suffering. 

    I’m wondering if this Huperzine A is worth a go – maybe it will help me get through?

    I see it also helps with stress and depression – I’ve got plenty of that through worry at the moment! 

  2. Yes I have heard of these and I tried some but it wasn’t the same provider. The ones that I tried were very good at the beginning then it felt like it did nothing. So what can you tell me that will make the differences between Huperzine and others that are in the market now. Other that they are natural. There needs to be something needs to stand out. 

    • When yo try supplements, not every one or every brand works for everyone.  We always say if that one didn’t work try another.

      A very good one is Onnit Alpha Brain that is a mixture of all natural products.

  3. After reading your post I find out the i did not know that this plant existed and the it will help you with  memory, for depression  looks interesting to try it.

    also that is almost for everyone and serves as prevention too My only thing sometimes about this type of medication is the side effects it makes me want to try it but at the same time the this side effect makes me think twice.

    Thank you for his info i will go to amazon to check the price 

  4. God and Indeed nature has blessed humanity with every necessary things for our sustainability and development. 

    I think a nootropic like Huperzine A should be readily available in every local medicine store due to it’snumerous benefits especially it’s ability to enhance memories and mental clarity.

    Students and  professionals need it to function at their utmost performance to make high grades and make outstanding discoveries to make the world a better place.

    It ability as a neuroprotectant as you said cannot be over emphasized and the side effects are not out of this world.

  5. I’ve struggled with memory recall for a very long time. I’ve tried a lot of supplements and they all seem to have unwanted side effects that aren’t worth the consequences. Would you say that huperzine A is a “cleaner” treatment. In other words, will it give me good memory recall without the symptoms of anxiety I get with other supplements? Thanks for the article

    • Yes I would.  Stick with the recommended dosages from the bottle,  maybe choose the lowest dose to start and move up.  You should be good to go.

  6. I have never heard of this smart drug.  I do like supplements and think they are important, there is a reason that a lot of our natural plants have healing powers.  Having the ability to have a clear mind and being able to learn is always important no matter your age.   I think this would be worth trying because if it doesn’t work you are not out much, if it does you stand to gain your life back.

    • Of course.  Not everyone responds the same so if you try it and it isn’t for you , so be it and try another.  Hperzine A is natural.

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