Phosphatidylserine Benefits

Spread the love

Introduction to Phosphatidylserine Benefits

Today is all about the phosphatidylserine benefits that are proving to be pretty exciting.  It’s a big word so this is why we can refer to it as PS.  It isn’t usually known for its nootropic benefits and phosphatidylserine benefits

unfortunately and I say that in all seriousness because this is a very very good nootropic.  Not only that, but it is in all known species found in the brain cell membranes.  It is responsible for all things cellular: cellular health, cellular structure, and cellular protection.  Unfortunately, it undergoes a steady decline as we age. If we keep up our optimum levels of Phosphatidylserine then we can enhance our cognitive performance, improve our memory retention, promote healthy mood, and slow cognitive ageing and decline [1].

So what is it really?  It is an amino acid derivative compound our bodies produce naturally.  We can also get it from our diets and obviously from supplements.

Phosphatidylserine is a phospholipid layer surrounding all cells.  It keeps the cell membranes flexible and fluid.  It promotes cellular healing and helps cells and their intake of important nutrients and flushing of waste.

How Does It Work

Phosphatidylserine is a fatty acid.  It enters the central nervous system by crossing the blood-brain barrier. Once it is in, it helps our brains metabolize glucose which is its primary source of energy.  Phosphatidylserine also promotes the release of several important neurotransmitters including acetylcholine which it also binds to.

Acetylcholine is responsible for enhancing our focus, memory, and reasoning. Low levels acetylcholine can impede your learning ability.

A 1993 study showed us that PS increases the number of brain synapses [2]. Synapses are the equivalent of bridges or links between neurons. Neurons are a type of brain cell and are the building block of the nervous system. More synapses equal improved efficiency and quality of communication between neurons, which benefits all cognitive functions.

Health Benefits of Phosphatidylserine

Improves Symptoms of Depression

It is fairly clear that taking PS will help depression symptoms.  Studies show that supplementing with PS at any age can drastically improve those symptoms of depression.

Late-life depression often is not very responsive to traditional anti-depression drugs so alternative therapies are needed.   Trials of the Phosphatidylserine along with Omega-3 Fatty Acids on elderly patients both male and female who are experiencing late-life depression showed that PS did reduce their depression symptoms and cognitive impairment as well as their memory [3].

For younger people, men taking Phosphatidylserine showed reduced symptoms of distress.  Children with depression who were given the supplement along with Omega-3 fatty acids had a marked improvement in their attention and cognition and found relief from their symptoms [4]

So we can see that Phosphatidylserine works on depression symptoms on all age groups and not just in age-related depression.

Benefits Children With ADD/ADHD

Here is a study showing the effectiveness of PS on children and not just adults.  36 children were selected all between the ages of 4 and 14 and diagnosed with a form of attention disorder whether ADD or ADHD.  They were given 200mg/day for a period of 2 months.

The result of the trial was that Phosphatidylserine was able to significantly enhance the children’s attention performance, memory, mood boosting, and stress relieving [5].  It does this through a reduction of cortisol levels. PS encourages increased brain activity through the neurotransmitters,  This enhances the ability of ADHD sufferers to focus, control impulses better and learn without becoming easily fatigued.

Boosts Athletic Performance

PS, through many studies, has shown that it can improve our athletic performance.  In addition, it can decrease muscle damage and at the same time improve the endocrine response to exercise-induced stress.

One study in 2007 took young healthy golfers and gave them oral Phosphatidylserine.  Six weeks later they concluded that PS improved their perceived stress levels and perhaps as a result improved their tee-offs [6]

Of these studies, another looked at the effects of 750mg/day of soybean-derived Phosphatidylserine given to male cyclists for a total of 10 days.  What they found was that taking PS supplements had significantly increased their exercise time to exhaustion to 85% VO2 max.

What is VO2 max?  It is the maximum rate of oxygen consumption measured during incremental exercise; that is, the exercise of increasing intensity.

Improves Memory

Phosphatidylserine has been studied and tested as a memory booster and is now proven to do just that.  One Japanese study that included 78 adults 50 years of age and older who had complaints of memory problems.  Taking Soy-PS (100 mg, 300 mg/day) or placebo for 6 months PS helped increase their overall memory scores and their verbal recall [7].

PS is also considered in Alzheimer’s research with studies showing mixed results.  However, there is some research showing Phosphatidylserine does support memory.  This is believed to be because it improves the levels of acetylcholine in our brains.

We will see what the future brings.

Can Slow Age-Related Cognitive Decline

Phosphatidylserine taken from bovine phospholipids shows it’s ability in elderly people to improve their memory, mod, and cognition.

One study consisted of 10 elderly women experiencing depressive disorders.  They were first given a placebo for 15 days and then the PS for 30 days.  What they found was that the PS produced a consistent improvement of their depressive symptoms, their memory, and their behaviour [8]

Reduces the Negative Effects of Stress

Cortisol is vital to our bodies and gives us boosts of energy when under stressful situations.  Basically, it fuels our “fight or flight” response.

There is a problem where cortisol is concerned.  If we have a high level over a long period of time we are at serious risk of Hyperglycemia, metabolic syndrome, hypertension, and a lot more.

This is where phosphatidylserine comes in.  It has been shown to reduce concentrations of cortisol in those who are subjected to mental stressors and to help the efficiency of the adrenal glands.  This is all in response to mental stress as described here.

Get Your Phosphatidylserine Naturallyphosphatidylserine benefits

Hmmm.  Do you like cow brains?  If you do, you are lucky because cow brains have the highest concentration of PS.  Amazing for you.  Just 100 grams of cow brains contains 713mg of PS.

Only one problem with that.  Yes, you could get mad cow disease or bovine spongiform encephalopathy as it is known as.  Ya, so don’t get it from cow brains.

Organ meats are the next best alternative to brains.  If you like kidney or liver then you are in luck.  These contain 414mg for every 100mg of the organs.  Oh, pig kidneys have 218mg in every 100mg if you are into that.

Organ meats are by far the best option for a good dose of PS without any health risks to you.  Not only that, but they have high sources of vitamin A, B vitamins, protein, iron, copper, folic acid, and CoQ10.

White beans and soybeans are other sources.   Soybeans and white beans each contain about 100 milligrams of phosphatidylserine per 100-gram serving.

Soybeans contain all the essential amino acids which are the building blocks of protein.  They contain omega-3 fatty acids, calcium, folate and iron. White beans, on the other hand, are a good source of protein and contain vitamin A and iron.  No worry of mad cow disease here either.]

So these are your sources of PS, but if you aren’t a fan of organs, you may just want to supplement your Phosphatidylserine.


Is Phosphatidylserine Safe?

There is nothing to indicate PHosphatidylserine isn’t safe.  None of the research done has shown any negative side effects from supplementing with PS.

One study was conducted or a seven month period and found no side effects taking 300mg.

You must take into consideration the dose you take.  If you increase the dose significantly you can run into the problems listed below

  • headache
  • irritability
  • gastro upset

These are all symptoms of first-time use or taking more than the recommended dose.


The recommended standard for adults is 100mg PS three times a day.  The total of 300mg in a day is considered both safe and very effective.

I always recommend that if you are taking it for the first time, start with a low dosage and work your way up to the suggested.  This way you will get a chance to see how you react.

If you pregnant or breastfeeding do not take it until you speak to your physician.  If you are taking antidepressants, antihistamines, or Alzheimer’s medications you should not take it until you speak to your physician.

Where to Buy it

The best place to get the best quality and service you need it is the Nootropics Depot.  Just click on the bottle to your right to get yours.

To Wrap it Up

First, let me say this is a very good supplement to take.  There has been quite a bit of research surrounding PS although many have a lower number of participants than we would like to see to be sure of the results.

The use of phosphatidylserine for ADD and ADHD seems pretty promising, especially for memory improvement.

Looking at physical performance is up to my ally and it seems promising as well.  I’d like to try this on myself to see if I see an improvement.

PS is considered another very safe supplement although there are a few reasons to consult your physician before taking PS.  They are listed above.

Leave a Comment